Optimal control of malaria chemotherapy

Optimal control of malaria chemotherapy

Abstract. We present an intra-host mathematical model of malaria that describes the interaction of the immune system with the blood stage malaria merozoites. The model is modified by incorporating the effects of malaria drugs that target blood stage parasites. The optimal control represents a percentage effect of the chemotherapy of chloroquine in combination with chlorpheniramine on the reprod...

Optimal control of the chemotherapy of HIV.

Using an existing ordinary differential equation model which describes the interaction of the immune system with the human immunodeficiency virus (HIV), we introduce chemotherapy in an early treatment setting through a dynamic treatment and then solve for an optimal chemotherapy strategy. The control represents the percentage of effect the chemotherapy has on the viral production. Using an obje...

Blasting neuroblastoma using optimal control of chemotherapy.

A mathematical model is used to investigate the effectiveness of the chemotherapy drug Topotecan against neuroblastoma. Optimal control theory is applied to minimize the tumor volume and the amount of drug utilized. The model incorporates a state constraint that requires the level of circulating neutrophils (white blood cells that form an integral part of the immune system) to remain above an a...

The chemotherapy of malaria.

Chemotherapy of malaria.

The recent war, which carried troops into al1 the highly malarious regions of the world, gave great impetus to the search for better antimalaria1 drugs. The greatest concerted effort was put forth in the United States under the guidance of the Board for Coordination of Malaria1 Studies. The principal objective was the discovery of a drug of low toxicity which would also be at least one of the f...